Goat Skin for Wound Healing

Wound healing is a complex process made up of three main stages: Inflammation – leaked blood coagulates with platelets and fibrin; and white blood cells, growth factors, enzymes and nutrients travel to the site of injury, Proliferation –  granulation tissue forms comprised of collagen and extracellular matrix.  Angiogenesis also occurs. Remodeling – collagen is remodeled … Continue reading Goat Skin for Wound Healing

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Bioengineered Lungs

This year researchers at the University of Texas Medical Branch have created lungs in the lab and successfully transplanted them into pigs.  The pigs survived for a few weeks after the procedure.  Whilst the procedure is in a very early stage the future looks promising.  If this procedure could be adapted for humans, patients requiring … Continue reading Bioengineered Lungs

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Biological Scaffolds

Biological scaffolds are produced by the decellularisation of tissues and organs. The extracellular matrix (ECM) is isolated from native cells and genetic material, leaving a scaffold. The ECM scaffold ideally retains its inherent structure and can be recellularised to produce a functional tissue or organ. Some clinical products composed of decellularised tissues already in use … Continue reading Biological Scaffolds

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Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that causes shortness of breath. The lungs become scarred, stiff and thick and the damage is irreversible. It can be caused by exposure to some environmental pollutants or certain medicines. The chemicals cause injury to alveolar epithelial cells and this promotes an immuno-inflammatory phase. This phase … Continue reading Idiopathic Pulmonary Fibrosis (IPF)

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Skin Fibrosis Research

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue. Skin or cutaneous fibrosis is caused by the accumulation of extracellular matrix components in the dermis.  It occurs naturally during wound repair and scar formation but can also be the result of pathological processes in pro-fibrotic diseases. Systemic sclerosis (SSc) or … Continue reading Skin Fibrosis Research

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