Scaffolds for Kidney Failure

End Stage Renal Disease (Kidney Failure)  may result in complete kidney failure.  When the kidneys totally fail, either dialysis or a kidney transplant is required.  With the rising number of patients needing renal replacement therapy new strategies are needed to treat kidney disease.

‘The aim of kidney tissue engineering is to develop and innovate methods of obtaining renal extracellular matrix (ECM) scaffolds derived from kidney decellularization’ (Karczewski,M. and Malkiewicz (2015).

These acellular scaffolds are then reseeded with stem cells.  Protocols for obtaining scaffolds have been developed successfully but the recellularisation step is the challenging part of the process (Remuzzi, A. et al., (2017).

Hussein et al. (2018) have decellularised porcine kidneys producing biocompatible scaffolds.  This represents ‘a step toward development of a transplantable organ’ Hussein et al. (2018).

References

Hussein, K. H., Saleh, T., Ahmed, E., Kwak, H.-H., Park, K.-M., Yang, S.-R., … Woo, H.-M. (2018). Biocompatibility and hemocompatibility of efficiently decellularized whole porcine kidney for tissue engineering. Journal of Biomedical Materials Research Part A, 106(7), 2034–2047. http://doi.org/10.1002/jbm.a.36407

Karczewski,M. and Malkiewicz (2015) Scaffolds from Surgically Removed Kidneys as a Potential Source of Organ Transplantation.  BioMed Research International Volume 2015, Article ID 325029, 8 pages.  Review Article.  http://dx.doi.org/10.1155/2015/325029).

Remuzzi,A., Figliuzzi,M., Bonandrini,B., Silvani,S., Azzollini,N., Nossa,R., Benigni,A. and Remuzzi,G. (2017) Experimental Evaluation of Kidney Regeneration by Organ scaffold Recellularization.  Sci Rep. 2017; 7: 43502https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339865/